On a 1991 Chevy 350 tbi if your injector wires are crossed will it still run but only with spit and sputter?

Yes, if the injector wires are crossed on a 1991 Chevy 350 TBI, it will likely run poorly, spitting and sputtering. The TBI system relies on a specific firing order and fuel delivery sequence to each cylinder. Crossing the wires disrupts this, leading to some cylinders receiving fuel at the wrong time or not at all, causing a rough, misfiring idle and poor performance. It won't necessarily prevent the engine from running altogether, but it will run very badly.