Can you use the transmission from a 1985 Chevy S-10 Blazer V6 4wd on 1988 Silverado 12 ton pick up 350 V8 2wd?

No, you cannot directly use the transmission from a 1985 Chevy S-10 Blazer V6 4WD on a 1988 Silverado 1-ton pickup 350 V8 2WD. The transmissions are completely different in terms of size, gearing, bolt patterns, and input/output shaft configurations. The S-10 Blazer transmission is a much smaller, lighter-duty unit designed for a smaller engine and potentially a different transfer case (since it's 4WD). The Silverado 1-ton truck requires a much heavier-duty transmission capable of handling significantly more torque and weight. Even if you could somehow bolt it up (which you can't), it would quickly fail under the load.