* Engine mounts: Custom engine mounts would need to be fabricated.
* Transmission: The 6.0L likely uses a different transmission than your Silverado 1500. You'll probably need a new transmission, driveshaft, and possibly the rear differential.
* Wiring harness: The engine's computer and wiring harness are incompatible. You'd need a custom harness or significant rewiring.
* Exhaust system: A new exhaust system would be required.
* Cooling system: The cooling system might need upgrades to handle the larger engine.
* Potential frame reinforcement: The added weight of the 6.0L might require frame reinforcement.
While technically possible with enough time, skill, money, and fabrication expertise, it's a massive undertaking far beyond a simple engine swap. It would likely be cheaper and easier to either find a used 2000 Silverado 1500 with a larger engine or consider a different engine swap that requires less modification. A 5.3L or 5.7L LS engine from the same era would be a far more realistic and straightforward swap for your truck.