* Clearance: The engine block, intake manifold, and accessories (alternator, power steering pump, etc.) would likely interfere with the firewall, inner fenders, and other components within the engine bay.
* Exhaust System: Routing the exhaust system would be a major challenge.
* Transmission: Matching the transmission to the 305 would require modifications, potentially including custom mounts.
* Mounting: Creating custom engine mounts would be necessary.
While some people undertake incredibly ambitious engine swaps, fitting a 305 into an Astro van without extensive fabrication and engineering is highly impractical. It's far more feasible to consider a smaller V6 swap or rebuilding the original engine.