* Wheel well clearance: The S-10's wheel wells are designed for much smaller diameter wheels. 20-inch rims, especially with wider tires, will likely rub against the fenders, body panels, or suspension components, even with smaller profile tires.
* Backspacing/Offset: The correct backspacing and offset are crucial for proper wheel fitment. A 20-inch wheel designed for a different vehicle will almost certainly have a different backspacing and offset than what's optimal for the S-10. This can lead to rubbing and potential damage to the vehicle.
* Brake caliper clearance: Larger diameter wheels can sometimes interfere with the brake calipers. This is less likely with 20" wheels on a truck, but it's still a possibility.
* Ride quality: Larger wheels often mean lower profile tires. Lower profile tires offer less sidewall which reduces the ability to absorb bumps and potholes, leading to a harsher ride.
While some people might make modifications to fit them (e.g., lift kit, fender flares, body modifications), it's a significant undertaking and might not be worth the effort or cost. Stick with wheel sizes recommended for your 1994 S-10 to avoid issues and ensure safe operation. Consult your owner's manual or a tire professional to determine the correct wheel and tire sizes for your truck.