No, unfortunately, a 95 S10 2.2 transmission will not fit into a 4.3 engine. The 2.2 and 4.3 engines have different bolt patterns and bellhousing configurations, so the 2.2 transmission will not be able to mate to the 4.3 engine. Additionally, the 2.2 transmission is not designed to handle the power and torque output of the 4.3 engine, so it would likely fail prematurely if installed.
If you are looking to swap a transmission into a 4.3 engine, you will need to find a transmission that is specifically designed for that engine. There are a number of aftermarket transmission options available that will fit the 4.3 engine, or you can also source a used transmission from a junkyard or salvage yard.
