• Ignition system problems: This could include spark plugs, spark plug wires, or the ignition coil.
• Fuel system problems: This could include a dirty or faulty fuel injector, or a problem with the fuel pump or fuel pressure regulator.
• Engine mechanical problems: This could include a vacuum leak, a bad piston or cylinder, or a problem with the valve train.
• Engine control computer problems: This could include a problem with the PCM (powertrain control module) or another engine sensor.
To narrow down the cause of the P0300 code in your Durango, you will need to do some further diagnostics. This may involve checking the spark plugs and wires, cleaning the fuel injectors, or testing the fuel pressure. If you are not comfortable performing these tasks yourself, you can take your Durango to a mechanic for diagnosis and repair.