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1999 S-10 4.3 vortex V6 only runs if fuel is poured into throttle body?

It sounds like you have a fuel delivery issue, and pouring fuel into the throttle body is a temporary fix, not a solution. Here's a breakdown of the potential causes and how to troubleshoot:

Possible Causes:

* Fuel Pump Failure: The most likely culprit is a failing fuel pump. It might not be providing enough pressure to reach the injectors.

* Fuel Filter Clogged: A clogged fuel filter can restrict fuel flow.

* Fuel Injector Problems: One or more injectors could be clogged or faulty, preventing fuel from being sprayed into the cylinders.

* Fuel Pressure Regulator Malfunction: A faulty regulator might not be maintaining the correct fuel pressure.

* Fuel Lines or Hose Issue: There could be a leak or blockage in the fuel lines leading to the engine.

* Wiring Issues: Problems with the wiring to the fuel pump, fuel injectors, or other components in the fuel delivery system could cause a lack of fuel supply.

* Electrical Short Circuit: A short in the wiring could interrupt the fuel pump's power supply.

* Fuel Pump Relay Problem: The relay that controls the fuel pump could be faulty.

Troubleshooting Steps:

1. Check for Fuel Pressure: You'll need a fuel pressure gauge to test the fuel pressure. If it's below the manufacturer's specification, this confirms a fuel delivery issue.

2. Inspect Fuel Filter: Check the fuel filter for dirt or debris. Replace it if necessary.

3. Test Fuel Injectors: You can use a fuel injector tester or ohmmeter to check for proper resistance.

4. Inspect Fuel Lines and Hoses: Look for leaks, cracks, or blockages in the fuel lines and hoses.

5. Inspect Fuel Pressure Regulator: Make sure the fuel pressure regulator is properly attached and functioning.

6. Inspect Fuel Pump Relay: Ensure the fuel pump relay is clicking when you turn the key to the "on" position.

7. Check Wiring: Inspect the wiring to the fuel pump, fuel injectors, and other components for damage or corrosion.

Important Safety Note: Working with fuel systems can be dangerous. Take precautions to prevent fire hazards and fuel spills.

Additional Tips:

* If you suspect a faulty fuel pump, it's usually best to replace it rather than try to repair it.

* If you're not comfortable working on your fuel system, take it to a mechanic for diagnosis and repair.

Let me know if you have any other questions, or if you'd like me to elaborate on any of these steps.