While you *could* theoretically adapt a late-model frame, it's a massive undertaking requiring extensive welding, custom fabrication of mounts, and a deep understanding of chassis engineering. It's far beyond a simple bolt-on swap. People do this for custom builds, but it's a major project that often involves significant cost and expertise.
Instead of adapting a late-model frame, consider these more realistic options for updating a 1948 F100:
* Frame Off Restoration/Upgrade: This involves restoring or replacing the existing frame, potentially upgrading components like the suspension (e.g., with a modern independent front suspension conversion kit designed specifically for that year).
* Using a similar vintage frame: Finding a frame from a truck of a similar era (perhaps slightly later, like a 1950s Ford truck) might be a more practical approach for a less extensive modification.
In short, while technically *possible* to adapt to a late-model frame, it's not *practical* for most people. The work required makes it a far more involved project than most people would undertake.