* Engine Bay Clearance: The 454 is considerably larger than the engines typically found in a '68 Nova. You'll likely need to modify or replace the firewall, possibly even the inner fenders. Some bodywork might be needed for clearance.
* Transmission and Drivetrain: The 454's torque will require a stronger transmission and drivetrain than a stock Nova would have. You'll likely need a beefier transmission (TH400 automatic is common), a stronger rear end (e.g., 12-bolt), and possibly upgraded axles and driveshaft.
* Suspension: The added weight of the 454 engine will put a lot of stress on the Nova's suspension. Upgrading suspension components (springs, shocks, sway bars) is highly recommended to handle the extra weight and power.
* Exhaust System: A custom exhaust system will be needed to accommodate the larger engine.
* Cooling System: The 454 will generate significantly more heat than the original engine. You'll likely need a larger radiator, electric fans, and possibly an upgraded water pump.
In short, while it's *possible*, fitting a 454 into a '68 Nova is a major undertaking requiring considerable mechanical expertise and fabrication skills, or significant financial investment in professional installation. It's not a project for a novice.