What you might be looking for, depending on specific issues you're having, could be:
* Ignition Control Module (ICM): This is a more likely candidate for a control unit. The ICM is part of the ignition system and handles spark timing and distribution. It's often found near the distributor or on the firewall. The location varies slightly depending on the exact engine configuration.
* Relay Modules: Various relays control fuel pump, ignition, etc. These are typically found in fuse boxes under the hood or inside the cab.
* Wiring harness: Issues with the wiring harness can mimic problems that might seem like a failing computer, but it is just a faulty connection or damaged wiring.
To find these components, you'll need:
1. Your truck's repair manual: This is the best resource. It will have diagrams showing the location of all components. A Haynes or Chilton manual would work.
2. Online forums: Search Ford E350 forums (like Ford-trucks.com) for information specific to your year and engine. Describe the problem you're having, as that will help people guide you to the correct component.
Instead of looking for an ECM, focus your search on the ICM, relays, and carefully inspect the wiring harness. If you're experiencing a specific problem (e.g., no spark, no fuel), describing that will help pinpoint the potential culprit much faster.