* Engine: The E-350 Super Duty has been offered with a wide range of gasoline and diesel engines over the years, each with dramatically different fuel economy. A gasoline V8 will get considerably worse fuel economy than a diesel V8.
* Transmission: Automatic vs. manual (though manuals are rare in this class of vehicle) will impact mileage.
* GVWR (Gross Vehicle Weight Rating): How much weight the vehicle is carrying significantly impacts fuel economy. A fully loaded E-350 will get far worse mileage than an empty one.
* Vehicle configuration: A van body will likely get slightly better mileage than a cutaway chassis used for a box truck.
* Driving style: Aggressive driving reduces fuel economy.
* Maintenance: Proper maintenance is key to optimal fuel efficiency.
* Year of manufacture: Newer models often incorporate technologies that improve fuel efficiency.
Therefore, there's no single answer to your question. You'll find a wide range of reported MPGs online, but they aren't directly comparable without knowing the specific configuration of the vehicle.
To find a more precise estimate, you should:
1. Specify the year and engine of the E-350 Super Duty: This is the most crucial piece of information.
2. Consult the EPA's fuel economy website (fueleconomy.gov): Search for the specific year, make, model, and engine. This will give you the official EPA estimates.
3. Check online forums and review sites: Look for user reviews of the specific E-350 model you're interested in. Keep in mind that user reports vary widely based on individual driving habits and conditions.
Expect significantly lower MPG than a typical passenger car; think in the range of 10-20 MPG, but possibly much lower depending on the factors listed above.