There's no single "gap size" for a 2000 Ford F-150 4.2L V6. Spark plug gap size depends on the specific spark plugs used. You
must consult your owner's manual or the packaging of the replacement spark plugs to find the correct gap.
Trying to find this information online without knowing the exact spark plug type is unreliable and could damage your engine. The wrong gap can lead to misfires, poor performance, and engine damage.