* Engine Bay Clearance: The S-10's engine bay is relatively small. A 350 V8 is considerably larger than the stock engine (likely a V6), requiring modifications to the firewall, possibly the inner fenders, and potentially even the hood.
* Transmission: You'll need a transmission compatible with the 350, likely a TH350, TH400, or a more modern automatic. The stock S-10 transmission won't work. This requires a new transmission crossmember and possibly driveshaft modifications.
* Motor Mounts: Custom motor mounts will be needed to properly position the engine in the bay.
* Exhaust System: A completely new exhaust system will be required.
* Wiring Harness: The wiring harness will need to be adapted or replaced to accommodate the 350.
* Cooling System: The stock cooling system may not be adequate for the larger engine. You'll likely need a larger radiator and possibly an upgraded cooling fan.
* Brakes: Upgrading the brakes is highly recommended for safety reasons due to the increased power of the 350.
* Suspension: The increased weight of the engine might require suspension upgrades to handle the extra load.
In short, while it's *possible*, it's a complex project requiring mechanical skills, fabrication abilities, and potentially a significant investment in parts and labor. It's not a job for a novice. You'll likely need to consult with experienced mechanics or swap shops for guidance and possibly assistance.