There are a number of possible causes for a misfire, including:
* Faulty spark plug: A spark plug that is not firing properly can cause a misfire.
* Faulty ignition coil: An ignition coil that is not providing enough power to the spark plug can also cause a misfire.
* Faulty injector: A fuel injector that is not delivering enough fuel to the cylinder can cause a misfire.
* Vacuum leak: A vacuum leak can cause a misfire by allowing unmetered air into the engine.
* Compression problems: Low compression in a cylinder can also cause a misfire.
If you are experiencing a misfire in your 2001 Ford Expedition, it is important to have it diagnosed and repaired as soon as possible to prevent further damage to the engine.