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95 S10 pickup rough running and misfiring?

Here are a few potential causes for a 1995 S10 pickup running rough and misfiring:

1. Spark Plugs: Worn-out or fouled spark plugs can cause misfires. Check the condition of your spark plugs and replace them if necessary.

2. Ignition System: Problems with the ignition system, such as a faulty ignition coil or distributor cap, can also lead to misfires. Inspect the ignition components and replace any damaged or worn parts.

3. Fuel System: Issues with the fuel system, such as a clogged fuel filter or faulty fuel injector, can affect the engine's air-fuel mixture and cause misfires. Check the fuel system components and clean or replace any faulty parts.

4. Vacuum Leaks: Vacuum leaks can disrupt the engine's air-fuel mixture and lead to misfires. Inspect the vacuum hoses and connections for leaks and repair or replace any damaged hoses.

5. Intake Manifold Gasket: A faulty intake manifold gasket can cause vacuum leaks and affect the engine's performance. Check the intake manifold gasket for leaks and replace it if necessary.

6. Oxygen Sensor: A faulty oxygen sensor can provide incorrect information to the engine's computer, affecting the air-fuel mixture and causing misfires. Check the oxygen sensor and replace it if it's faulty.

7. PCM (Powertrain Control Module): Issues with the PCM, such as a software glitch or hardware failure, can affect the engine's operation and lead to misfires. This may require professional diagnosis and repair or reprogramming of the PCM.

It's important to have the vehicle diagnosed by a qualified mechanic to properly identify the cause of the rough running and misfiring and make the necessary repairs. Ignoring these issues can lead to further damage and affect the vehicle's performance and reliability.