2WD:
- City: 16 mpg
- Highway: 22 mpg
4WD:
- City: 15 mpg
- Highway: 21 mpg
As you can see, there is a slight difference in fuel economy between the 2WD and 4WD models of the 2006 Ford Explorer. The 2WD model gets slightly better fuel economy than the 4WD model, both in the city and on the highway. This is because the 4WD system adds weight to the vehicle, which reduces fuel efficiency.
If you are looking for the most fuel-efficient 2006 Ford Explorer, then the 2WD model is the better choice. However, if you need the added traction and capability of 4WD, then you should be aware that there will be a slight decrease in fuel economy.