According to the EPA, the 2000 Cadillac Deville with the 4.6-liter V8 engine gets an estimated 18 MPG in city driving and 27 MPG on the highway. The 2000 Cadillac Deville with the 5.0-liter V8 engine gets an estimated 17 MPG in city driving and 25 MPG on the highway.
It's important to note that these are EPA-estimated MPG ratings, and actual fuel efficiency may vary depending on factors such as driving style, traffic conditions, weather conditions, and vehicle condition.