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What would be cause for continuous bump in driver rear wheel area of 1999 Ford F150 XLT when driving forward and occasional grabbing nearly locking up side wheel?

There are a few potential causes for a continuous bump in the driver rear wheel area of a 1999 Ford F150 XLT when driving forward, as well as occasional grabbing and nearly locking up of the side wheel. Here are some things to consider:

1. Wheel Bearing Issues: Worn or damaged wheel bearings can cause a bumping or grinding noise, as well as play or looseness in the wheel when it's lifted off the ground. If the wheel bearings are severely worn, it can lead to the side wheel grabbing or locking up.

2. Brake Problems: Issues with the brakes, such as a seized brake caliper or a damaged brake rotor, can cause the side wheel to grab or lock up. Over time, warped rotors or seized brake components can also create an intermittent grinding or bumping sound.

3. Driveline Issues: A faulty driveshaft or a damaged differential can cause vibrations, bumping noises, or sudden grabbing of the side wheel. These components transmit power from the engine to the wheels, and if they're worn or damaged, it can lead to abnormal behaviour.

4. Suspension Components: Worn or damaged suspension components, such as control arms, ball joints, or tie rods, can cause knocking or bumping noises when driving over uneven surfaces or when turning. If these components are loose or worn, it can also affect the wheel alignment and cause the side wheel to grab or lock up.

5. Tire Problems: Uneven tire wear, a damaged tire, or a tire with a bulge can cause bumping noises and affect the vehicle's handling. A loose lug nut or wheel bolt can also lead to the side wheel grabbing or locking up.

To diagnose the exact cause of the bump and occasional grabbing in the rear wheel area, it's recommended to have a qualified mechanic inspect the vehicle. They will be able to lift the vehicle, inspect the wheels, brakes, suspension components, and driveline to determine the root cause of the issue and recommend the necessary repairs.