The key interlock mechanism is a safety feature that prevents you from removing the key from the ignition switch while the transmission is in gear. If the key won't come out, make sure the transmission is in Park (for automatic transmissions) or neutral (for manual transmissions).
Steering Wheel Locked
If the steering wheel is locked, the key won't come out of the ignition switch. To unlock the steering wheel, turn the key to the "On" position and then turn the steering wheel gently from side to side until it unlocks.
Key Deformed or Damaged
If the key is deformed or damaged, it may not be able to engage the ignition switch properly. Try using a different key or having the key repaired or replaced.
Ignition Switch Faulty
If the ignition switch is faulty, it may not be able to release the key. You may need to have the ignition switch repaired or replaced.
Broken Linkage
A broken linkage between the ignition switch and the lock cylinder can prevent the key from being released.
Foreign Objects
If there is a foreign object in the ignition switch, it may prevent the key from being released. Check for any debris or dirt that may have gotten into the switch and remove it carefully.
If none of these solutions work, you should take your vehicle to a qualified mechanic to have the problem diagnosed and repaired.