* Transmission type: The specific type of manual transmission (e.g., NV3500, SM465, etc.) used varies across years and models. Even if both trucks have a manual transmission, the bellhousing bolt pattern (where the transmission connects to the engine) might differ.
* Clutch: The clutch system, including the pressure plate, clutch disc, and throwout bearing, is specific to the transmission and likely won't be interchangeable.
* Driveshaft: The length and yoke style of the driveshaft are often different between models and years, meaning the S-10's driveshaft might not fit the 1500's differential.
* Crossmember: The transmission crossmember (which supports the transmission) might need modification or replacement to fit the different transmission.
* Wiring: While unlikely to be a major issue, there might be slight differences in the wiring harness connections.
In short, while it *might* be possible with extensive modifications (new crossmember, custom driveshaft, potentially clutch and bellhousing), it's far from a simple swap. You'd likely be better off sourcing a manual transmission from a similar year 1993-1997 Chevy 1500 or other compatible GM truck to avoid significant fabrication and potential compatibility problems. Consult a mechanic or transmission specialist before attempting this swap.