* For most 4.3L V6 engines: The fuel filter is typically located on the frame rail, near the fuel tank, on the driver's side. It's often a cylindrical canister-type filter.
* For the 2.9L V6 engines: The location is *generally* similar to the 4.3L, though possibly slightly different in access. Again, check near the fuel tank on the driver's side frame rail.
To be absolutely certain:
1. Consult your owner's manual: This is the best resource. It will have a diagram showing the location.
2. Use a repair manual: A Haynes or Chilton repair manual for your specific year and engine will have detailed diagrams and instructions.
3. Search online: A Google image search for "2001 Chevrolet Astro fuel filter location" along with your engine size (4.3L or 2.9L) will show pictures that can help you pinpoint it.
Remember safety first! Work in a well-ventilated area and be aware of fuel system pressures. If you're not comfortable working on your vehicle yourself, take it to a qualified mechanic.