Major Considerations:
* Engine Mounts: The 350's mounting points won't align with the Regal's original engine bay. You'll need custom motor mounts, likely fabricated or purchased from a specialist.
* Transmission: The Regal's original transmission won't likely mate to the 350. You'll need a compatible transmission (e.g., TH350, TH700R4, 700R4, or a manual transmission like a T5 or a Muncie) and likely a custom adapter plate or bellhousing.
* Exhaust System: The exhaust system will need to be entirely custom-fabricated to fit the 350 and its headers or manifolds.
* Wiring Harness: The Buick's original wiring harness won't work with the 350. You'll either need a custom harness or modify the existing one, which can be complex and requires electrical knowledge. You'll also need to consider the alternator, starter, and other electrical components' compatibility.
* Cooling System: The 350's cooling system requirements may differ from the Regal's. You may need a different radiator, water pump, and hoses.
* Driveshaft: The driveshaft will likely need to be shortened or replaced to accommodate the different transmission and engine dimensions.
* Fuel System: The fuel system will probably need modifications to support the 350's fuel needs. This may involve a new fuel pump, lines, and possibly a different fuel pressure regulator.
* Brakes: Consider upgrading the brakes to handle the increased power of the 350.
* Computer Control (if applicable): Depending on the year and configuration of the 350, you may need to deal with computer control issues. A carbureted setup is often simpler than fuel injection.
Steps Involved (General Overview):
1. Research and Planning: Thoroughly research the swap before you start. Gather all necessary parts and tools. Read forums and articles specific to this swap.
2. Engine Removal and Bay Preparation: Remove the original engine and transmission. This may require disconnecting various components, such as the power steering and A/C.
3. Fabrication: This is the most challenging part. You'll need to fabricate or purchase custom motor mounts, exhaust, transmission adapter (if needed), and potentially other components.
4. Installation: Carefully install the 350, transmission, and related components.
5. Wiring: Wire the engine and all related components to the car's electrical system.
6. Fuel System Installation: Install the necessary fuel lines, pump, etc.
7. Exhaust System Installation: Install your custom exhaust system.
8. Cooling System Installation: Install the radiator, hoses, and water pump.
9. Driveshaft Installation: Install or modify the driveshaft.
10. Testing and Tuning: Thoroughly test the engine and make any necessary adjustments.
In short: This is a major project that's best tackled by someone with significant mechanical experience and access to the right tools and equipment. Don't underestimate the complexity and time involved. Consider seeking the assistance of a professional mechanic experienced in engine swaps.