* Modern Challengers (2008-present): It's highly unlikely to fit without significant, extensive modifications. The engine bay is relatively compact, even in the widebody versions. You'd likely need custom engine mounts, headers, possibly firewall modifications, and potentially even modifications to the chassis structure. It would be a major undertaking, likely requiring professional fabrication.
* Classic Challengers (1970-1974): While a *larger* engine bay than the modern Challengers, fitting a 572 still presents serious challenges. The considerable size and width of the 572 would necessitate significant modifications, including custom headers, possibly modifying or relocating the radiator and other components, and potentially custom-fabricated engine mounts.
In short, while not technically impossible for *either* generation, it's a far from straightforward swap. It would be a very involved and expensive project requiring significant fabrication skills and expertise. You'd be looking at a substantial custom build rather than a simple bolt-in swap.