The main challenge lies in the fact that Ford and Chevy engines have different designs, and the engine bay of a Chevy pickup is specifically designed to accommodate a Chevy engine. Installing a Ford engine would require significant modifications to the engine mounts, engine control unit (ECU), wiring harness, exhaust system, and other components.
It would be necessary to source a compatible Ford engine, along with the necessary engine mounts and other components. It would also be necessary to modify the Chevy pickup's engine bay and electrical system to accommodate the Ford engine.
This type of modification is complex, time-consuming, and expensive. It is important to carefully consider the pros and cons before undertaking such a project, and to seek the advice of experienced professionals before proceeding.