However, a good estimate for a full system drain and refill is between 12 and 15 quarts of coolant/water mixture. Always check your owner's manual if you have it. Failing that, you'll want to locate your coolant reservoir. Often, it will indicate a "full" line. It's crucial to never overfill the system.
Important Note: Coolant should always be mixed with distilled water according to the manufacturer's instructions (usually a 50/50 mix). Using straight coolant or the wrong mix can damage your engine. Refer to your owner's manual or the coolant container for specific mixing instructions.