98 Chevy s10 trans 5 speed bolt up to 350 Chevy?

No, a 98 Chevy S10 5-speed transmission will not directly bolt up to a 350 Chevy small-block engine. The S10 transmission's bellhousing is designed for the smaller S10 engine's bolt pattern, which is significantly different from that of a 350 Chevy small block. You'll need an adapter plate or a transmission specifically designed for the 350 to make it work.