* Engine type: The E350 has used various engines over the years (gasoline V6s, V8s, and diesel V8s). Diesel engines, generally, are known for longer lifespans than gasoline engines, but proper maintenance is key for all.
* Maintenance: Regular oil changes, filter replacements, and other scheduled maintenance are crucial. Neglecting maintenance drastically shortens engine life.
* Driving habits: Aggressive driving, frequent towing heavy loads, or consistently operating at high RPMs will wear down an engine faster.
* Operating conditions: Extreme temperatures (both hot and cold) and dusty environments can put extra stress on the engine.
While some E350 engines might reach 200,000 miles or even more with diligent care, others might fail significantly sooner due to neglect or harsh conditions. There's no guaranteed mileage; it's all about how well it's maintained and used. Instead of focusing on a specific mileage number, prioritize regular maintenance to maximize the engine's lifespan.