No, a 350 Turbo Hydra-Matic transmission (TH350) will generally
not bolt directly to a 4x4 pickup truck transfer case. The TH350's output shaft is designed for a two-wheel drive application. 4x4 trucks require a transfer case to distribute power to the front and rear axles, and the TH350 lacks the necessary mating surface or configuration for this.
You would need an adapter, which may or may not exist depending on the specific truck and transmission. Even with an adapter, it's a complex and potentially unreliable solution. It's far more common and practical to use a transmission designed for 4x4 applications in a 4x4 truck.
