No, a 1997 Chevy C2500's 305 Vortec computer (PCM) is unlikely to properly control a 350 without significant modifications or a replacement PCM. While they might share some basic components, the differences in displacement, fuel delivery requirements, and potentially even the engine's internal sensors (like the crankshaft position sensor signal) are substantial enough to prevent successful operation. The PCM's fuel and ignition maps are calibrated specifically for the 305; using it with a 350 would result in poor performance, potential damage to the engine, or even a complete failure to start.
You'd need either:
* A PCM programmed for a 350: This is the most reliable solution. You'll need a PCM from a similar-year C2500 or equivalent vehicle with a 350, or one that's been professionally reprogrammed.
* A standalone engine management system (EMS): This offers complete control and flexibility, but is considerably more expensive and complex to install.
In short, don't attempt this without professional help or extensive knowledge of engine management systems. The risk of engine damage is significant.
