* Year of the truck: Engine technology and emissions standards changed over the years the S-10 was produced (roughly 1982-2004), significantly impacting fuel efficiency. Older trucks will generally have lower MPG.
* Transmission: Automatic or manual transmissions affect fuel economy. Automatics tend to be slightly less efficient.
* Drivetrain: 2WD (two-wheel drive) trucks generally get better gas mileage than 4WD (four-wheel drive) trucks.
* Driving habits: Aggressive acceleration and high speeds drastically reduce fuel economy. City driving typically yields lower MPG than highway driving.
* Vehicle condition: Proper maintenance (tune-ups, tire inflation, etc.) is crucial for optimal fuel efficiency.
To get a reasonable estimate, you'd need to specify the year and options of the S-10. Even then, the actual mileage will vary. You can try searching online for fuel economy data specific to the year and model of your S-10, or consult the owner's manual (if you have it). Sites like fueleconomy.gov (for US vehicles) might offer some general ranges, but they won't be perfectly accurate for a specific vehicle.