To be sure, you need to:
1. Determine the bolt pattern: Find the number of lug nuts and the diameter of the circle they form (e.g., 5x4.75", 5x120.65mm, etc.). This is critical. Different bolt patterns will *not* fit.
2. Check the wheel backspacing and offset: These determine how far the wheel sits in the wheel well. Incorrect backspacing can cause rubbing against the suspension or body. Get this information for both the S-10 wheels and your Blazer's wheels. Ideally, they should be close.
3. Compare wheel diameter and width: While the diameter might be compatible (allowing for tire size changes), the width of the S-10 wheels shouldn't be drastically different from the Blazer's original wheels. Too wide and it might rub, too narrow and it might look odd or not fit securely.
If the bolt pattern, backspacing, and offset are all very close, then the S-10 wheels *probably* will fit. However, it's always best to double-check the specifications before purchase to avoid problems. A local tire shop can help you confirm compatibility.