```
Cost = (Distance / MPG) * Cost per Gallon
```
Plugging in the given values, we get:
```
Cost = (400 miles / 14 MPG) * $3.75 per gallon
```
```
Cost = 28.57 gallons * $3.75 per gallon
```
```
Cost = $107.18
```
Therefore, it will cost approximately $107.18 to drive 400 miles in a van that gets 14 MPG and gas costs $3.75 per gallon.