Engine problems: The 250-cubic-inch inline-six engine that came standard in the C10 was not particularly powerful and was prone to overheating. The 283-cubic-inch V8 was a better option, but it could also have issues with overheating and oil leaks.
Transmission problems: The three-speed manual transmission that came standard in the C10 was not particularly durable and could be difficult to shift. The four-speed manual transmission was a better option, but it could also have problems with shifting.
Suspension problems: The C10's suspension was not particularly sophisticated and could be prone to bouncing and swaying. This could be especially noticeable when the truck was loaded with cargo or towing a trailer.
Brakes: The C10's brakes were not particularly powerful and could be prone to fading. This could be especially dangerous when the truck was loaded with cargo or towing a trailer.
Electrical problems: The C10's electrical system was not particularly reliable and could be prone to problems with the lights, wipers, and horn. This could be especially dangerous when driving at night or in inclement weather.