The AC filter (cabin air filter) on a 2004 Mercedes-Benz E250 van is typically located
behind the glove box. To access it, you'll usually need to remove or partially remove the glove box itself. The exact procedure might vary slightly depending on the specific trim level and options, but that's the general location.
Before you start, consult your owner's manual. It will have the most accurate and detailed instructions for your particular van. A quick online search for "2004 Mercedes-Benz E250 cabin air filter replacement" will also likely yield helpful videos or diagrams.