- 1886: Karl Benz's Benz Patent-Motorwagen (the first internal combustion engine-powered automobile)
- 1889: Gottlieb Daimler and Wilhelm Maybach's Daimler Stahlradwagen (the first four-wheeled automobile with an internal combustion engine)
- 1893: Duryea Motor Wagon (the first gasoline-powered automobile built in the United States)
- 1896: Ford Quadricycle (the first car made by Henry Ford)
- 1901: Oldsmobile Curved Dash (the first mass-produced automobile)
- 1908: Model T Ford (the first car to be produced on an assembly line, making it affordable for many Americans)
- 1910: Chevrolet Series C (the first car produced by the Chevrolet Motor Company)
- 1920: Packard Single-Six (the first car with an engine block made of cast aluminum)
- 1922: Duesenberg Model A (the first American-built car to win the 24 Hours of Le Mans race)
- 1924: Chrysler Imperial (the first American-built luxury sedan)