* Engine Bay Space: The 460 is significantly larger than the engines originally offered in the '65 F-100. You'll likely need to modify or fabricate motor mounts, possibly even trimming the firewall or inner fenders.
* Transmission: The transmission and associated components (driveshaft, etc.) will need to be compatible with the 460. This might involve using a different transmission entirely.
* Exhaust System: A custom exhaust system will be required.
* Cooling System: The larger engine will require a more robust cooling system. A larger radiator and potentially an electric fan may be needed.
* Steering: Depending on the accessories and size of the 460 setup, steering clearance may be an issue.
In short, while it's *possible*, it's a significant undertaking requiring mechanical expertise, fabrication skills, and potentially custom parts. It's not a simple swap.
