The EPA estimated MPG for a 2001 Ford F-150 with the 4.2L V6 engine varies depending on the configuration (cab style, drivetrain, etc.). You won't find a single definitive number. However, you can expect fuel economy in the range of
14-17 mpg combined (city and highway). Highway mileage will be slightly better than city mileage.
To get the most accurate MPG for a specific truck, you should check the original window sticker (if available) or resources like the Kelley Blue Book website, which often includes fuel economy data based on trim level.
